Black Hole by David Lynch
Charles Burns' Black Hole is a monster of a graphic novel, both figuratively and literally, and a true classic of the form. But the simple fact that the story revolves around high school kids fucking one another, contracting an STD that transforms them into often bizarre monsters, and then shooting one another means that this will never be made as a studio picture despite Universal commissioning a (very good) script from Neil Gaiman and Roger Avary and David Fincher expressing the desire to direct. Fincher's version would be too expensive by far and the combination of underage sex, drugs and firearms means it would likely never be able to secure an acceptable rating.
So take it out of Fincher's hands and give it to another David. Lynch's best work has always revolved around the dirty underbelly of middle America and I cannot imagine a better thematic fit. The Lynch version would likely look very little like Burns' drawings on the page but, seriously, can you imagine someone making this any more uncomfortable than Lynch would?